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    Compounds

    The frontier — NAD+ precursors, senolytics, autophagy enhancers, and other niche bioactives at the leading edge of longevity research. Evidence is evolving fast; quality and bioavailability vary widely.

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    Clinical lens

    A clinical lens on compounds supplements

    The longevity-supplement lane is where biology, hype, and capital intersect — discipline matters more than novelty.

    Use this lane to assemble the small, boring, evidence-based stack that compounds quietly over decades.

    Best used for
    • →Foundational longevity stacks
    • →Senolytic and autophagy support
    • →Mitochondrial maintenance
    • →Long-horizon supplementation
    Signal map
    • Human evidence is rare in this lane
    • Biomarkers matter more than mechanism stories
    • Stack discipline beats stack size
    • Cost-per-benefit varies enormously
    Decision questions
    • Could I cut my stack in half and lose nothing?
    • Am I optimising biology or chasing trends?
    • What biomarker tells me this is working?

    From the editor

    Goal · Longevity

    The minimum viable longevity stack

    Database · Research

    Aging biology research, scored

    Program · Peak 5 RI

    Where supplements sit in the full Peak 5 RI process

    Key benefits

    • •NAD+ restoration and sirtuin activation
    • •Senolytic clearance of senescent cells
    • •Autophagy and metabolic flexibility
    • •Glucose and lipid optimization

    Key considerations

    • •Long-term human data still emerging
    • •Bioavailability varies wildly by source
    • •Some require medical supervision (Rapamycin)

    Ideal for

    Proactive longevity protocols
    Cellular health optimization
    Metabolic optimization

    Notable compounds

    NMN
    NR (Nicotinamide Riboside)
    Resveratrol
    Quercetin
    Fisetin
    Spermidine
    Berberine
    Rapamycin
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    Longevity Operator

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    The Peak Human Score · PHS v1

    One number for your longevity journey.

    FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.

    • Metabolic
    • Hormonal
    • Cardiovascular
    • Brain / Cognitive
    • Sleep
    • Musculoskeletal
    • Gut
    • Immunity / Inflammation
    See your Peak Human Score How it works