MTHFR (C677T, A1298C)
MTHFR encodes an enzyme central to folate metabolism and methylation, and common variants (C677T and A1298C) reduce its activity. A preventive practice tests it once because reduced function can raise homocysteine and impair methylation, informing targeted B-vitamin support.
What It Measures
Methylenetetrahydrofolate reductase variants affecting folate metabolism.
Optimal vs. Lab Range
Target range for optimal health and longevity based on research.
Population-based reference range from standard labs.
Why It Matters
Reduced enzyme activity → elevated homocysteine, methylation impairment.
When Low
—
When Optimal
Wild-type → normal enzyme activity.
When High
Homozygous → 60–70% reduced activity; methylated B-vitamins recommended.
How to Optimize
Use methylated B-vitamin forms; monitor homocysteine; adequate B2/B6/B12/folate.
Key Interventions & Linked Compounds
Moderate (6/10)Key Interventions
Linked Compounds & Supplements
Curated from clinical literature. Individual results vary; consult a qualified clinician before changing a protocol.
Ordering Notes
Specimen
Buccal swab or whole blood (EDTA)
Patient prep
No fasting required. Maintain usual diet and medications unless advised.
Recommended cadence
Re-test every 3–6 months when actively optimizing; annually for monitoring.
Reporting unit
genotype
Pre-analytic notes
Standardize draw time of day, hydration, and recent exercise. Note any acute illness, supplements, or hormonal therapies on the requisition.
Recommended Follow-Up Actions
- 1
Confirm the result is reliable
Repeat abnormal values before acting — preferably from the same lab, same time of day, and under consistent prep. Rule out acute illness, recent intense exercise, or medication effects that can shift MTHFR (C677T, A1298C).
- 2
Compare against optimal, not just lab range
Use the optimal window above as the target. Lab "normal" is built from the general population and often misses early dysfunction.
- 3
Pair with related markers
Order a complementary panel covering metabolic, inflammatory, and hormonal context to interpret this marker properly.
- 4
Discuss interventions with a clinician
Use the interpretation guidance above to frame the conversation. Bring trends, not just one datapoint, to your visit.
- 5
Re-test on a defined cadence
If a change is implemented, re-measure in 8–12 weeks for fast-moving markers, or 3–6 months for slower ones, to confirm response before escalating.
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