Peak HumanDatabase
    ●peakhuman@intel:~/database/feeds/patents$
    ts 2026-09-17 00:38:23last_sync 00:00:00filings 12/12unread 12saved 0
    --view
    preview corpus· live patent ingestion from USPTO/EPO/WIPO XML drops in next sprint.
    ▸cmd :: filters
    $
    --cat
    --office
    --status
    --auto
    ▸stream :: 12 filings
    cat=all office=all status=all
    [001]Cellular reprogramming via small-molecule cocktail without viral vectorsRetro Biosciencesusptopending11 months

    ↳ US 2025/0211904 · A six-compound cocktail inducing partial cellular rejuvenation with epigenetic age reversal of 4.6 years in primary fibroblasts after 14 days of exposure.

    [002]★AAV-mediated yamanaka factor delivery with tissue-specific promoterAltos Labsepogranted12 months

    ↳ EP 4,512,883 · AAV9 capsid variants delivering a polycistronic OSK cassette under a hepatocyte-specific promoter for partial epigenetic reprogramming without loss of cell identity.

    [003]★CAR-T platform targeting senescence-associated surface antigensDeciduous Therapeuticswipopublished12 months

    ↳ WO 2025/118402 · Chimeric antigen receptor T-cells engineered against uPAR and B2M-derived neo-epitopes preferentially expressed on senescent cells in fibrotic and oncologic indications.

    [004]★Senolytic combination therapy targeting BCL-XL and FOXO4 pathwaysUnity Biotechnologyusptogranted1 year

    ↳ US 11,938,162 · A pharmaceutical composition combining a small-molecule BCL-XL inhibitor with a FOXO4-DRI peptide for the selective clearance of senescent cells in age-related tissue dysfunction, with reduced thrombocytopenia profile.

    [005]★Engineered klotho variants with extended half-life for cognitive agingKlotho Neuroscienceswipopublished1 year

    ↳ WO 2025/041337 · Recombinant α-klotho fusion proteins fused to an Fc domain demonstrating 6-fold serum half-life extension and improved blood-brain barrier penetrance in non-human primate models.

    [006]Closed-loop AI dosing for mTOR inhibitors using digital biomarkersBioAge Labsepopending1 year

    ↳ EP 4,498,221 · A reinforcement-learning controller adjusting weekly rapalog dose based on wearable-derived HRV, sleep, and grip-strength inputs to maximize healthspan score.

    [007]Exosome-loaded mitochondria for cellular bioenergetic restorationMitrix Biocnipapublished1 year

    ↳ CN 118,372,109 · Exogenous mitochondria packaged inside engineered exosomes for systemic delivery and uptake by aged or ischemic tissues, restoring ATP output by 38% in murine cardiac models.

    [008]Multi-omic biological age estimator using methylation and proteomic signalTally Healthusptopendingover 1 year

    ↳ US 2025/0173821 · A method and system for computing biological age from a combined epigenetic clock and circulating proteomic panel, calibrated against a 28,000-subject longitudinal cohort.

    [009]Rapamycin analog with reduced immunosuppressive profileTornado Therapeuticsjpopublishedover 1 year

    ↳ JP 2025-118842 · An mTORC1-selective rapalog reducing FKBP12-FRB binding affinity to mTORC2, preserving lifespan-extension benefits while minimizing T-cell suppression.

    [010]Generative model for de novo design of NAD+ precursor analogsInsilico Medicineusptograntedover 1 year

    ↳ US 11,902,441 · Use of a transformer-based generative neural network conditioned on enzyme-binding pocket geometry to discover novel NMN/NR analogs with improved oral bioavailability.

    [011]Continuous glucose-ketone dual sensor with subcutaneous microarrayLevels Healthusptopendingover 1 year

    ↳ US 2025/0089213 · A microneedle array sensor with paired enzymatic electrodes for simultaneous interstitial glucose and beta-hydroxybutyrate monitoring, enabling closed-loop metabolic optimization.

    [012]Plasma proteomic panel for cardiovascular event predictionSomaLogicusptograntedover 1 year

    ↳ US 11,876,003 · A 27-protein aptamer-based blood panel predicting 4-year MACE risk with AUC 0.83, validated across three independent prospective cohorts (n=22,400).

    ▸sys :: snapshot
    filings.total 12
    filings.shown 12
    offices.live 5
    cats.tracked 7
    feed.head 11 months ago
    ▸topk :: assignees
    ▸topk :: topics
    ▸links :: nav
    cd ../feedscd ../newscd ../researchcd ../protocolscd ../stockscd ../../companies
    -- mode READ -- buf 12 --peakhuman.intel · patents.feed.v0.10 · 00:38:23
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