NAD+ IV Therapy
Intravenous infusion of nicotinamide adenine dinucleotide to restore cellular energy, support DNA repair, and activate longevity pathways.
Evidence Summary
Strong mechanistic basis from longevity research. Clinical evidence growing for addiction, fatigue, and cognitive function. Large RCTs pending. UPDATE (August 2026): A Nature Aging 2026 meta-analysis of >15,000 human methylation profiles across 17 tissues identified a modifiable, NAD+-metabolism-linked gene cluster distinct from age-associated clusters that beneficial interventions fail to move, which the authors present as support for NAD+ as a therapeutic target in aging. This strengthens the mechanistic rationale for the NAD+ axis generally. It says nothing about route of administration, and there remains no peer-reviewed human evidence that intravenous NAD+ outperforms oral precursors or improves any aging outcome. Large RCTs remain absent.
Evidence Scale
Mechanism of Action
NAD+ is essential coenzyme for metabolism, DNA repair (PARP), and sirtuin activation. IV delivery bypasses oral degradation and achieves supraphysiological levels.
Who Is This For?
Fatigue, cognitive decline, addiction recovery, anti-aging. Slow infusion rate essential.
Protocol & Dosing
Dose
250-1000mg per infusion depending on goals and tolerance.
Frequency
Daily loading, then weekly/monthly
Duration
4-10 day loading phase common
Protocol Summary
IV infusion of NAD+ over 2-6 hours. Slow infusion rate critical to minimize side effects.
Interactions & Precautions
Contraindications
- None absolute
- Caution with cardiac arrhythmias
Potential Risks
- •Discomfort during infusion
- •Cost
Potential Side Effects
Practitioner Notes
Clinical annotations from Dr. Goel
Start with lower doses and slower rates. Consider oral NMN/NR for maintenance between infusions. Combine with supportive nutrients. Updated August 2026: The 2026 cross-tissue methylation atlas supports the NAD+ axis at a network level but offers no support for IV delivery specifically. Keep the distinction explicit with patients - mechanistic plausibility for NAD+ metabolism is not evidence for NAD+ infusions. Cost and infusion burden still lack a matching evidence base.
Dr. Sanjeev Goel
Chief Medical Officer, Peak Human
Cost & Access
Cost Range
$$$
Accessibility
Availability varies by location
Sample member
Longevity Operator
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