Resveratrol
Polyphenol sirtuin activator found in red wine, studied extensively for cardiovascular and anti-aging effects.
Evidence Summary
Strong mechanistic evidence. Human trials mixed but show benefits for glucose metabolism and inflammation. Bioavailability challenges limit effects.
Evidence Scale
Mechanism of Action
Activates SIRT1 and AMPK, mimicking some effects of caloric restriction. Antioxidant and anti-inflammatory properties. May enhance mitochondrial function.
Who Is This For?
Cardiovascular support, anti-aging, metabolic health. Enhanced when combined with NAD+ precursors.
Protocol & Dosing
Dose
150-500mg daily trans-resveratrol.
Frequency
Daily with meals
Duration
Ongoing
Protocol Summary
Oral with fat-containing meal for absorption. Trans-resveratrol preferred. Often combined with NMN.
Interactions & Precautions
Contraindications
- Anticoagulant therapy (caution)
- Hormone-sensitive conditions (high doses)
Potential Risks
- •Bioavailability limitations
- •Drug interactions
Potential Side Effects
Practitioner Notes
Clinical annotations from Dr. Goel
Trans-resveratrol superior to cis form. Synergistic with NMN. Take with fat. Consider pterostilbene as alternative with better bioavailability.
Dr. Sanjeev Goel
Chief Medical Officer, Peak Human
Cost & Access
Cost Range
$
Accessibility
Availability varies by location
Sample member
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