Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women

Neil Carleton, Alexander Chih-Chieh Chang, Adrian V. Lee

1. 01

   Age-associated inflammation in breast tissue creates a tumour-permissive microenvironment

2. 02

   Altered estrogen disposition and metabolism accompanies the inflammatory shift

3. 03

   Findings replicated across aged rat model, human patient tissue and patient-derived organoids

4. 04

   Suggests host aging biology, not only tumour genotype, shapes late-onset ER+ breast cancer

Study Design

Translational Study

Sample Size

Not reported

Study Duration

Not reported

Methodology

Aged rat model, human patient tissue samples and patient-derived organoids, profiled for inflammatory and estrogen-metabolic differences by age.

Limitations

Hypothesis-generating and cross-sectional in the human arm. Does not establish causality, does not test any intervention, and has no bearing on whether exogenous hormone therapy increases or decreases this risk.