Peak HumanDatabase
    All Research
    PAPER AGING-methodological_analysis2026

    Criteria for confidence in epigenetic clock results in intervention studies (title not verified; DOI 10.1111/acel.70756)

    Per a secondary summary, extending previously published single-clock intervention studies to additional clock models produced no additional significant results; three criteria for higher-confidence clock findings are proposed. Journal inferred from DOI prefix (Aging Cell).

    Evidence

    5/10

    Emerging Evidence

    Sample

    —

    subjects

    Duration

    —

    study period

    Journal

    Aging Cell (inferred from DOI prefix; verify)

    Oct 2026

    02

    Key Findings

    1. 01

      No additional clocks reached significance when single-clock intervention studies were extended to more clock models

    2. 02

      Higher confidence when reliable PC-based clocks respond

    3. 03

      Higher confidence when mortality-trained or pace-of-aging clocks respond

    4. 04

      Higher confidence when multiple clocks move in the same direction

    03

    Structured Methods

    Study Design
    methodological_analysis
    Sample Size
    Not reported
    Study Duration
    Not reported
    Methodology
    Re-analysis of published intervention datasets, positive-control datasets and simulation
    Limitations
    Title, authors, sample sizes and exact publication date were not verified (primary page not accessible; details from a secondary summary); publication_date is approximate.
    04

    Citations & References

    Cite this paper

    Unknown authors (2026). Criteria for confidence in epigenetic clock results in intervention studies (title not verified; DOI 10.1111/acel.70756). Aging Cell (inferred from DOI prefix; verify).

    Source

    Publisher

    Journal

    Aging Cell (inferred from DOI prefix; verify)

    05

    Indexing

    Topics

    epigenetic clocksmethodology

    Interventions

    biological age testing
    PHS
    671
    / 1000
    T3
    Longevity Operator

    Sample member

    Longevity Operator

    The Peak Human Score · PHS v1

    One number for your longevity journey.

    FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.

    • Metabolic
    • Hormonal
    • Cardiovascular
    • Brain / Cognitive
    • Sleep
    • Musculoskeletal
    • Gut
    • Immunity / Inflammation
    See your Peak Human Score How it works