Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells
Supports a clearance-failure model of senescent-cell accumulation; cell and mouse data only. Journal inferred from DOI prefix (Nature Aging); verify.
Evidence
4/10
Emerging Evidence
Sample
—
subjects
Duration
—
study period
Journal
Nature Aging (inferred from DOI)
Oct 2026
Full Abstract
CMA deficiency in macrophages impairs senescent-cell clearance; pharmacological CMA activation reduced senescent burden in aged mice.
Key Findings
- 01
SASP from CMA-deficient senescent cells suppresses CMA in macrophages
- 02
Macrophage-specific CMA blockade increased senescent-cell accumulation in mice
- 03
Pharmacological CMA activation reduced senescent burden in aged mice and pulmonary fibrosis severity
Structured Methods
- Study Design
- Preclinical Study
- Sample Size
- Not reported
- Study Duration
- Not reported
- Methodology
- Cell culture and mouse models
- Limitations
- Mouse/cell only; compounds, effect sizes and sample sizes not verified from the primary text; human relevance untested.
Citations & References
Unknown authors (2026). Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells. Nature Aging (inferred from DOI). https://doi.org/10.1038/s43587-026-01240-w
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