Direct AMPK activation by compound 991 extends lifespan in yeast, worms and flies
No mouse lifespan extension shown; higher doses shortened lifespan in some experiments. Contrasts with indirect AMPK activation by metformin.
Evidence
3/10
Emerging Evidence
Sample
—
subjects
Duration
—
study period
Journal
Aging Cell
Oct 2026
Full Abstract
Direct allosteric AMPK activator 991 extended lifespan in S. pombe, C. elegans and Drosophila; short mouse study showed molecular AMPK signatures only.
Key Findings
- 01
Lifespan extension in yeast, worms and flies; lost without functional AMPK in worms and yeast
- 02
3-week mouse treatment: liver signatures of AMPK activation, mTOR suppression, mitochondrial biogenesis
- 03
No mammalian lifespan or healthspan data
Structured Methods
- Study Design
- Preclinical Study
- Sample Size
- Not reported
- Study Duration
- Not reported
- Methodology
- Invertebrate/yeast lifespan assays; short-term mouse liver proteomics
- Limitations
- Invertebrate/yeast lifespan only; sample sizes and statistics not verified from the full text; narrow dose window.
Citations & References
Rallis C (2026). Direct AMPK activation by compound 991 extends lifespan in yeast, worms and flies. Aging Cell. https://doi.org/10.1111/acel.70721
Sample member
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