Plasma GFAP is an early marker of amyloid-beta but not tau pathology in Alzheimer's disease
In the BioFINDER-2 cohort, plasma GFAP increased early and tracked amyloid-beta rather than tau, indicating astrocyte reactivity to amyloid.
Evidence
7/10
Moderate Evidence
Sample
—
subjects
Duration
—
study period
Journal
Brain
Nov 2021
Key Findings
- 01
Plasma GFAP rises early and tracks amyloid-beta rather than tau
- 02
Supports GFAP as a marker of amyloid-associated astrocyte reactivity
Structured Methods
- Study Design
- Cohort Study
- Sample Size
- Not reported
- Study Duration
- Not reported
- Methodology
- Not reported
- Limitations
- Not reported
Citations & References
Unknown authors (2021). Plasma GFAP is an early marker of amyloid-beta but not tau pathology in Alzheimer's disease. Brain.
Source
Publisher
Journal
Brain
Sample member
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