Longevity factor klotho enhances cognition in aged nonhuman primates

S. A. Castner, S. Dudek, D. Dubal

1. 01

   Single low-dose peripheral administration of alpha-klotho improved cognition in aged rhesus monkeys

2. 02

   Cognitive benefit outlasted the circulating half-life of the administered protein

3. 03

   Effect occurred at a dose not expected to cross the blood-brain barrier appreciably, implying an indirect peripherally initiated mechanism

4. 04

   Provides the strongest non-human primate rationale for klotho-directed cognitive therapeutics

Study Design

Preclinical Study

Sample Size

Not reported

Study Duration

Not reported

Methodology

Peripheral administration of recombinant alpha-klotho to aged rhesus macaques with subsequent cognitive testing.

Limitations

Non-human primate study — no human data. Small cohort typical of primate work. Single-dose design; chronic dosing safety and durability untested. The mechanism by which a peripherally administered dose produces central cognitive effects is not established. No approved alpha-klotho product exists for any indication.