Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials

Lin CR, Tsai SHL, Huang KY, Tsai PA, Chou H, Chang SH

1. 01

   4 RCTs, 507 patients with knee osteoarthritis

2. 02

   Significant pain reduction versus placebo (SMD -0.58, 95% CI -0.98 to -0.18)

3. 03

   No significant difference in adverse events versus placebo

Study Design

Meta-Analysis

Sample Size

507 subjects

Study Duration

Not reported

Methodology

Not reported

Limitations

Only 4 trials included; heterogeneity in collagen source/dose across studies; moderate rather than high certainty of evidence per GRADE.