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    PAPER NFL-PLDiagnostic Study

    Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort

    Established age-stratified one-sided reference intervals for plasma NfL in approximately 1,100 cognitively unimpaired adults (ages 20-95); NfL increased about 3% per year of age.

    Evidence

    7/10

    Moderate Evidence

    Sample

    —

    subjects

    Duration

    —

    study period

    Journal

    Clinica Chimica Acta

    02

    Key Findings

    1. 01

      Age-stratified NfL reference intervals in cognitively healthy adults

    2. 02

      NfL rises ~3% per year with age

    3. 03

      Sex did not significantly alter intervals

    03

    Structured Methods

    Study Design
    Diagnostic Study
    Sample Size
    Not reported
    Study Duration
    Not reported
    Methodology
    Not reported
    Limitations
    Not reported
    04

    Citations & References

    Cite this paper

    Unknown authors (n.d.). Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort. Clinica Chimica Acta.

    Source

    Publisher

    Journal

    Clinica Chimica Acta

    05

    Indexing

    Topics

    reference rangebrain aging

    Biomarkers

    NfL
    PHS
    671
    / 1000
    T3
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    Sample member

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