Physical activity delays ovarian aging in part through adiponectin-related signaling pathways

Biao Li, Nana Zheng, Jihui Zhang

1. 01

   Lower physical activity associated with menopause in cross-sectional human cohort analysis

2. 02

   Exercise delayed ovarian aging in mice, at least partly via increased adiponectin

3. 03

   An adiponectin receptor agonist reproduced the protective effect without exercise

4. 04

   Nominates the adiponectin axis as a pharmacological target for reproductive longevity

Study Design

Translational Study

Sample Size

Not reported

Study Duration

Not reported

Methodology

Cross-sectional analysis of human cohorts for the physical activity-menopause association, plus murine exercise intervention and adiponectin receptor agonist pharmacology.

Limitations

The human arm is cross-sectional and observational; it cannot establish direction of effect and is vulnerable to reverse causation (declining ovarian function reducing activity). All interventional data are murine. No adiponectin receptor agonist is approved for human use.