TNFR1 signaling connects inflammation to impaired fatty acid oxidation to drive intestinal stem cell aging

Ruixuan Wang, Tahmineh Tabrizian, Derek M. Huffman

1. 01

   TNFR1 signalling links circulating inflammation to intestinal stem cell functional decline

2. 02

   Mechanism runs through impaired fatty acid oxidation in the stem cell compartment

3. 03

   Aged intestinal stem cell phenotype is transferable from old to young mice via shared circulation

4. 04

   Positions systemic inflammaging, not cell-intrinsic aging alone, as the driver

Study Design

Preclinical Study

Sample Size

Not reported

Study Duration

Not reported

Methodology

Mouse genetic and parabiosis (shared circulation) experiments with intestinal stem cell functional and metabolic profiling.

Limitations

Entirely murine. No human data. TNF-axis blockade is available clinically but carries infection and malignancy risk and has never been tested for an aging or gut-regeneration indication; this study does not support off-label use.