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    PAPER TOPICAClinical Trial2026

    Topical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity

    Topical UA increased mitochondrial respiration and mitophagy markers in skin models, and in placebo-controlled studies reduced periorbital wrinkle depth at 8 weeks and attenuated UVB-induced erythema. Details from a Fight Aging! summary; journal inferred from DOI prefix (iScience); sample sizes, funding and conflicts not verified.

    Evidence

    4/10

    Emerging Evidence

    Sample

    —

    subjects

    Duration

    —

    study period

    Journal

    iScience (inferred from DOI; verify)

    Oct 2026

    01

    Full Abstract

    Topical urolithin A tested in reconstructed human skin, ex vivo explants and randomized placebo-controlled studies in healthy volunteers.

    02

    Key Findings

    1. 01

      Increased mitochondrial respiration and mitophagy markers in 2D/3D skin models and ex vivo explants

    2. 02

      Reduced inflammatory and senescence markers; increased ECM and epidermal differentiation proteins

    3. 03

      Reduced periorbital wrinkle depth after 8 weeks in randomized placebo-controlled studies

    4. 04

      Attenuated UVB-induced erythema

    03

    Structured Methods

    Study Design
    Clinical Trial
    Sample Size
    Not reported
    Study Duration
    Not reported
    Methodology
    Reconstructed human skin models, ex vivo human skin explants, randomized placebo-controlled studies in healthy subjects; skin transcriptomics
    Limitations
    Topical, cosmetic/skin-function endpoints only; sample sizes not verified; funding and conflicts not verified; journal and publication date approximate. Does not inform systemic or oral urolithin A effects.
    04

    Citations & References

    Cite this paper

    Unknown authors (2026). Topical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity. iScience (inferred from DOI; verify). https://doi.org/10.1016/j.isci.2026.117646

    DOI

    10.1016/j.isci.2026.117646

    Source

    Publisher

    Journal

    iScience (inferred from DOI; verify)

    05

    Indexing

    Topics

    urolithin Amitophagyskin

    Interventions

    urolithin-a
    PHS
    671
    / 1000
    T3
    Longevity Operator

    Sample member

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