A transitional senescence program drives inflammatory monocyte state expansion in aging humans

Vasilopoulos T, Turano PS, Garza-Martinez L, Akbulut E, Konda M, Herbig U, Fitzgerald-Bocarsly P, Martinez-Zamudio RI

1. 01

   Variance of SA-bGal higher in older donors; mean not significantly different

2. 02

   Pseudotime suggests bridge from classical monocytes to inflammatory state; AP-1 dynamics

3. 03

   Older-donor monocytes ~2.2-fold enriched in sepsis-associated MS1 state

Study Design

Preprint

Sample Size

66 subjects

Study Duration

Not reported

Methodology

Flow cytometry, bulk RNA/ATAC-seq, single-cell multiome

Limitations

Preprint. Single-cell multiome only 4 young/3 older donors; trajectory inference and sepsis links correlative; AP-1 not tested experimentally in reviewed portions; posting date inferred from DOI.