ApigeninNew
A flavone found in chamomile, parsley, and celery, popularized as a sleep and hormonal-support supplement, often paired with magnesium. Human clinical evidence for these specific uses remains very limited despite promising preclinical mechanisms.
Mechanism of Action
Apigenin binds GABA-A receptors with mild benzodiazepine-like activity in animal models, the proposed basis for its sedative/anxiolytic reputation. It also inhibits aromatase and 17β-hydroxysteroid dehydrogenase in cell-culture models, the basis for claims about testosterone support, though these effects have not been confirmed at achievable oral doses in humans.
Dosing Protocol
50mg before bedmg
Standard starting dose based on research
Therapeutic Range
25
Minimum
100
Maximum
Evening, 30-60 minutes before bed
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- Reported sleep-onset support (largely anecdotal/preclinical)
- Antioxidant and anti-inflammatory activity in preclinical models
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Pregnancy/breastfeeding (insufficient safety data)
- •Hormone-sensitive conditions (theoretical aromatase-inhibition concern, unconfirmed in humans)
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- Standardized extract (e.g., from chamomile or parsley) with stated apigenin content
- Third-party tested
- Often formulated with magnesium for combined sleep support
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
3/10
Emerging/Anecdotal
Limited clinical data, primarily mechanistic studies or user reports
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
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