Citicoline (CDP-Choline)New
A water-soluble choline donor and phospholipid precursor studied for memory support in older adults and for neuroprotection in stroke and cognitive impairment.
Mechanism of Action
Citicoline is hydrolyzed to cytidine and choline, which cross the blood-brain barrier and are re-synthesized into phosphatidylcholine for neuronal membrane repair; it also supports acetylcholine synthesis and dopamine signaling and may reduce phospholipid breakdown after ischemic injury.
Dosing Protocol
500mg per day (EFSA supplement ceiling: 500 mg/day)
Standard starting dose based on research
Therapeutic Range
250
Minimum
1000
Maximum
Morning with breakfast; split into two doses if using above 500 mg
Cycling Protocol
Studied continuously for 8-12 weeks in healthy older adults; reassess benefit after 3 months
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- Episodic and composite memory support in aging adults
- Neuronal membrane (phosphatidylcholine) support
- Choline supply for acetylcholine synthesis
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Pregnancy and breastfeeding (insufficient data)
- •Hypotension or parasympathetic overactivity (rare reports)
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- Branded forms (e.g. Cognizin) used in published RCTs
- Dose per capsule clearly listed (250-500 mg)
- Third-party tested
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
5/10
Moderate Evidence
Some clinical trials with positive results, emerging research
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
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