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    Citrus Bergamot (Polyphenolic Fraction)New

    Supplement
    Cardiovascular Support
    4/10 Evidence

    A flavonoid-rich extract of Citrus bergamia (bergamot orange) studied for lowering LDL cholesterol, triglycerides and glucose. Trial results are consistently favourable but short, small, and often from a single research group, so it is best viewed as an adjunct to diet, exercise and, where indicated, statins.

    Mechanism of Action

    Bergamot flavonoids (neoeriocitrin, neohesperidin, naringin, melitidin, brutieridin) inhibit HMG-CoA reductase through a statin-like HMG-flavanone mechanism, may reduce intestinal cholesterol absorption, and activate AMPK, with antioxidant and anti-inflammatory effects on the endothelium.

    Dosing Protocol

    Recommended

    500mg per day of bergamot polyphenolic fraction (BPF), typically 38-47% flavonoids

    Standard starting dose based on research

    Therapeutic Range

    500

    Minimum

    to

    1000

    Maximum

    mg per day of bergamot polyphenolic fraction (BPF), typically 38-47% flavonoids

    With or before a meal, once daily or split in two doses; allow 8-12 weeks, then recheck lipids

    Cycling Protocol

    Studied continuously for 30 days to 12 months; recheck a fasting lipid panel at 8-12 weeks and discontinue if there is no response

    Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.

    Benefits

    Primary Benefits

    • Lower LDL cholesterol and total cholesterol in adults with mild-to-moderate hypercholesterolaemia
    • Lower triglycerides in several trials

    Secondary Benefits

    Possible improvement in fasting glucose and insulin sensitivity
    Possible benefit for fatty liver markers and carotid intima-media thickness (small trials)
    May allow lower statin dose in statin-intolerant patients (limited data)

    Safety Information

    Contraindications

    Do not use if any of the following apply:

    • •Pregnancy and breastfeeding (insufficient data)
    • •Citrus allergy
    • •Active liver disease
    • •Use with statins or other lipid drugs only with clinician oversight

    Drug/Supplement Interactions

    May interact with the following. Consult a healthcare provider before combining:

    Statins — additive LDL lowering; monitor for muscle symptoms and liver enzymes
    CYP3A4-metabolised drugs (some calcium-channel blockers, immunosuppressants) — citrus flavonoids may alter levels; bergamot is less studied than grapefruit
    Antidiabetic drugs — additive glucose lowering
    Anticoagulants — theoretical, limited data

    Potential Side Effects

    Some users may experience:

    Heartburn and GI upset
    Nausea
    Muscle cramps (rare)
    Photosensitivity applies to topical bergamot oil, not to polyphenolic extracts

    This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.

    Quality Markers

    Look for these specific quality indicators when sourcing this compound:

    • Standardised to total flavonoid content (neoeriocitrin, neohesperidin, naringin)
    • Extract of juice or albedo, not essential oil
    • Label states mg of BPF, not mg of whole fruit
    • Third-party tested

    Trusted Certifications

    NSF Certified
    USP Verified
    GMP Certified
    ConsumerLab Approved

    Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.

    Evidence Profile

    Evidence Score

    4/10

    Emerging/Anecdotal

    Limited clinical data, primarily mechanistic studies or user reports

    Classification:
    Emerging/Moderate (4-5 range; scored 4). A 2020 systematic review (Lamiquiz-Moneo et al., Critical Reviews in Food Science and Nutrition; 12 human studies) reported LDL reductions of about 7.6% to 40.8%, total cholesterol 12.3% to 31.3% and triglycerides 11.5% to 39.5%, with good tolerability over 30 days to 12 weeks. No pooled randomized meta-analysis was found. A commonly cited 237-patient dose-ranging trial (1,000 mg/day: LDL about -36%) was seen only via a secondary summary. Effect sizes vary widely, most trials are short and open to industry or single-centre bias, and there are no hard cardiovascular-outcome trials. Evidence

    Evidence Scale

    8-10

    Strong

    5-7

    Moderate

    1-4

    Emerging

    PHS
    671
    / 1000
    T3
    Longevity Operator

    Sample member

    Longevity Operator

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