DHEA (Dehydroepiandrosterone)New
Adrenal-derived steroid hormone precursor that declines roughly 80% from age 25 to 75; among the most-studied endocrine interventions in longevity medicine for body composition, bone density, and mood in older adults with confirmed low levels.
Mechanism of Action
Converts peripherally to testosterone and estradiol via steroidogenic enzymes; modulates GABA-A and NMDA receptors; exerts anti-glucocorticoid effects that may buffer cortisol-driven insulin resistance and systemic inflammation.
Dosing Protocol
25mg
Standard starting dose based on research
Therapeutic Range
25
Minimum
50
Maximum
Morning, to mimic the natural circadian peak
Cycling Protocol
Physician-supervised only — requires baseline and follow-up DHEA-S, testosterone, and estradiol labs; reassessed every 3-6 months, not a self-directed cycle
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- Restores age-related hormone decline (in confirmed low DHEA-S)
- Modest fat mass reduction
- Bone mineral density support in deficient older adults
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Hormone-sensitive cancers (breast, prostate, ovarian)
- •Pregnancy/breastfeeding
- •Undiagnosed vaginal bleeding
- •PCOS (may worsen androgen excess)
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- USP-verified micronized DHEA
- Baseline and follow-up DHEA-S lab confirmation before and during use
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
5/10
Moderate Evidence
Some clinical trials with positive results, emerging research
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
Sample member
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