EGCG (Green Tea Extract)New
The dominant catechin in green tea and the most-studied polyphenol for metabolic health and body composition — a notable gap in a Polyphenols category that already covered Fisetin, Quercetin, Resveratrol, Spermidine, Apigenin, and Honokiol.
Mechanism of Action
Activates AMPK, inhibits catechol-O-methyltransferase to potentiate norepinephrine-driven lipolysis, favorably modulates gut microbiota, and downregulates NF-κB inflammatory signaling; shows mild senomorphic activity in preclinical aging models.
Dosing Protocol
400mg EGCG (standardized, decaffeinated extract)
Standard starting dose based on research
Therapeutic Range
250
Minimum
800
Maximum
With food, split into two doses, to reduce GI and liver-enzyme irritation risk
Cycling Protocol
Continuous use at standard doses; avoid exceeding 800mg/day — especially fasted — due to a hepatotoxicity signal seen at high doses in case reports
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- Body composition / fat oxidation support
- Cardiometabolic marker improvement (lipids, blood pressure)
- Antioxidant and anti-inflammatory activity
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Pre-existing liver disease
- •Pregnancy (high-dose extract)
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- Decaffeinated, standardized to ≥45% EGCG
- Third-party tested; taken with food, not fasted
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
6/10
Moderate Evidence
Some clinical trials with positive results, emerging research
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
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