Milk Thistle (Silymarin)New
The classic hepatoprotective herbal extract, standardized to silymarin flavonolignans, widely used for liver enzyme support and as an adjunct in fatty-liver and detoxification protocols — introducing a Liver Support category to the compound map.
Mechanism of Action
Silibinin stabilizes hepatocyte cell membranes, scavenges free radicals, upregulates glutathione synthesis, and inhibits fibrogenic TGF-β signaling implicated in hepatic fibrosis.
Dosing Protocol
300mg standardized extract (70-80% silymarin), divided 2-3x/day
Standard starting dose based on research
Therapeutic Range
140
Minimum
600
Maximum
With meals
Cycling Protocol
Studied continuously for 3-12 months; reassess liver panel periodically during use
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- Liver enzyme (ALT/AST) support
- Hepatoprotection against toxin- or drug-induced injury
- Antioxidant support for detox pathways
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Ragweed/Asteraceae family allergy
- •Hormone-sensitive conditions (mild estrogenic activity reported)
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- Standardized to ≥70% silymarin
- Phytosome/phospholipid-complexed forms (e.g. Siliphos) for improved bioavailability
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
5/10
Moderate Evidence
Some clinical trials with positive results, emerging research
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
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