Myo-InositolNew
A naturally occurring sugar-alcohol that acts as an insulin second messenger precursor, used for insulin sensitivity and PCOS, with mixed randomized-trial evidence.
Mechanism of Action
Myo-inositol is a precursor of inositol phosphoglycans and phosphatidylinositol signalling molecules that mediate insulin and FSH receptor signalling; supplementation may improve insulin sensitivity and ovarian signalling, particularly in women with PCOS.
Dosing Protocol
4000mg per day (often 2 g twice daily; PCOS trials frequently use a 40:1 myo- to D-chiro-inositol ratio)
Standard starting dose based on research
Therapeutic Range
2000
Minimum
4000
Maximum
Twice daily, morning and evening; powder dissolved in water is common
Cycling Protocol
No formal cycling; most trials run 3-6 months. Reassess HbA1c, fasting insulin or cycle regularity after 3 months.
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- Improved insulin sensitivity in some populations (PCOS, metabolic syndrome)
- Menstrual regularity and ovulation support in PCOS
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Bipolar disorder on lithium (consult prescriber)
- •Pregnancy unless directed by an obstetric provider
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- Pure myo-inositol (pharmaceutical grade), with ratio stated if combined with D-chiro-inositol
- Label states grams per serving
- Third-party tested
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
4/10
Emerging/Anecdotal
Limited clinical data, primarily mechanistic studies or user reports
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
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