Panax Ginseng (Korean/Asian Ginseng)New
The root of Panax ginseng, a traditional adaptogen standardized to ginsenosides and studied for fatigue, cognition and glycemic control. Human evidence is suggestive but inconsistent, and a 2024 review of randomized trials found no conclusive support for any specific disease.
Mechanism of Action
Ginsenosides (Rb1, Rg1, Rg3 and others) modulate the hypothalamic-pituitary-adrenal axis, AMPK and NF-kB signaling, and nitric-oxide production. Preclinical data suggest antioxidant, anti-inflammatory and neuroprotective effects; gut-microbiome conversion to compound K affects bioavailability, so response varies between individuals.
Dosing Protocol
200mg per day standardized extract (about 4-7% ginsenosides); 1-3 g/day dried root
Standard starting dose based on research
Therapeutic Range
100
Minimum
400
Maximum
Morning or midday; avoid evening dosing because of stimulant-like effects
Cycling Protocol
Commonly used 8-12 weeks followed by a 2-4 week break, or 2-3 weeks on and 1 week off; no long-term safety data beyond about 6 months
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- Reduced fatigue (small effect) in chronic fatigue and cancer-related fatigue
- Support for mental performance and mood with short-term use
- Support for post-meal glucose control in some trials
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Pregnancy and breastfeeding
- •Uncontrolled hypertension or arrhythmia
- •Bipolar disorder or mania history
- •Hormone-sensitive conditions — theoretical estrogenic activity, use clinician guidance
- •Before surgery — stop about 2 weeks prior (bleeding and glucose effects)
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- Panax ginseng (not American ginseng or Siberian eleuthero) stated on the label
- Standardized ginsenoside content and root age/source declared
- Third-party tested for pesticides and heavy metals
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
4/10
Emerging/Anecdotal
Limited clinical data, primarily mechanistic studies or user reports
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
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