Pine Bark Extract (Pycnogenol)New
A standardized extract of French maritime pine bark rich in procyanidins, studied for blood pressure, circulation, joint comfort and skin. Evidence is mixed and much of it comes from trials linked to the manufacturer of the branded extract.
Mechanism of Action
Procyanidins and phenolic acids scavenge free radicals, inhibit NF-kB and COX-2 inflammatory signalling and may increase endothelial nitric oxide synthase activity, supporting vasodilation. Effects appear specific to standardized extracts (about 65-75% procyanidins).
Dosing Protocol
100mg per day of standardized extract (65-75% procyanidins)
Standard starting dose based on research
Therapeutic Range
50
Minimum
200
Maximum
Daily with food, once or divided twice daily
Cycling Protocol
No established cycling. Reassess benefit (blood pressure, joint symptoms) after 8-12 weeks and stop if no benefit
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- A 2020 Phytotherapy Research meta-analysis of 12 trials (922 participants) reported small blood-pressure reductions (SBP -3.2 mmHg, 95% CI -5.5 to -0.9; DBP -1.9 mmHg)
- A 2020 Angiology review restricted to double-blind placebo-controlled RCTs found no significant systolic benefit (WMD -0.03 mmHg), so the blood-pressure signal is not settled
- Small trials report reduced pain and stiffness in knee osteoarthritis at 100 mg/day (no systematic review located)
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Bleeding disorders or planned surgery within 2 weeks
- •Autoimmune disease or transplant on immunosuppressants
- •Pregnancy and breastfeeding (insufficient data)
- •Known pine or conifer allergy
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- Standardized to 65-75% procyanidins
- Branded, trial-tested extract (e.g. Pycnogenol) rather than generic bark powder
- Third-party tested for heavy metals and solvent residues
- Dose stated in mg of extract, not mg of bark
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
4/10
Emerging/Anecdotal
Limited clinical data, primarily mechanistic studies or user reports
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
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