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    PterostilbeneNew

    Supplement
    Polyphenols
    3/10 Evidence

    A dimethylated analog of resveratrol with roughly four times the oral bioavailability, studied for metabolic, cardiovascular and cognitive aging. Human evidence rests on a handful of small trials, with a signal for blood pressure but an LDL cholesterol increase.

    Mechanism of Action

    Two methoxy groups increase lipophilicity and metabolic stability compared with resveratrol, improving absorption and half-life. Preclinical work shows activation of Nrf2 and SIRT1-linked pathways, PPAR-alpha agonism, and antioxidant and anti-inflammatory effects.

    Dosing Protocol

    Recommended

    100mg per day (trial doses 100-250 mg per day, split)

    Standard starting dose based on research

    Therapeutic Range

    50

    Minimum

    to

    250

    Maximum

    mg per day (trial doses 100-250 mg per day, split)

    With a meal containing fat; split doses if above 100 mg

    Cycling Protocol

    No established cycling protocol; human trials lasted 6-8 weeks, so periodic breaks and lipid re-testing are reasonable

    Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.

    Benefits

    Primary Benefits

    • Possible blood-pressure lowering at higher doses (single small trial)
    • Antioxidant and anti-inflammatory support
    • Higher bioavailability than resveratrol

    Secondary Benefits

    Possible cognitive and neuroprotective effects (preclinical, early human work)
    Used alongside NAD+ precursors in combination products (limited trial data)

    Safety Information

    Contraindications

    Do not use if any of the following apply:

    • •Pregnancy and breastfeeding (insufficient data)
    • •Elevated LDL cholesterol without monitoring
    • •Hormone-sensitive cancers — theoretical estrogen-receptor activity, clinician guidance

    Drug/Supplement Interactions

    May interact with the following. Consult a healthcare provider before combining:

    Antihypertensives — additive blood-pressure lowering
    Diabetes medications — possible additive glucose lowering
    CYP substrates (e.g. warfarin) — possible inhibition of CYP enzymes; monitor
    Statins and lipid-lowering drugs — pterostilbene effect on LDL may be blunted

    Potential Side Effects

    Some users may experience:

    Rise in LDL cholesterol
    Mild GI upset
    Rare headache or dizziness

    This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.

    Quality Markers

    Look for these specific quality indicators when sourcing this compound:

    • Label states pterostilbene mg per serving (not trans-resveratrol)
    • Trans-pterostilbene, third-party tested for purity
    • Avoid proprietary blends that hide the dose

    Trusted Certifications

    NSF Certified
    USP Verified
    GMP Certified
    ConsumerLab Approved

    Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.

    Evidence Profile

    Evidence Score

    3/10

    Emerging/Anecdotal

    Limited clinical data, primarily mechanistic studies or user reports

    Classification:
    Emerging — one randomized, double-blind, placebo-controlled trial of 80 adults with high cholesterol (125 mg twice daily for 6-8 weeks) reported lower systolic and diastolic blood pressure (-7.8 and -7.3 mmHg) versus placebo, but LDL cholesterol rose by roughly 17 mg/dL, with the increase attenuated in people on cholesterol medication or when combined with grape extract. I found no systematic review or large independent trial; most data are preclinical. Scored Emerging (3). Evidence

    Evidence Scale

    8-10

    Strong

    5-7

    Moderate

    1-4

    Emerging

    PHS
    671
    / 1000
    T3
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