Saffron Extract (Crocus sativus)New
A standardized extract of Crocus sativus stigmas (active constituents crocin and safranal) taken for mood, anxiety and sleep support, with small but fairly consistent randomized-trial evidence for self-reported symptoms.
Mechanism of Action
Crocin and safranal are thought to modulate serotonergic, dopaminergic and glutamatergic signalling (including weak serotonin reuptake inhibition and NMDA/GABA-A effects), and to reduce neuroinflammation and oxidative stress; these mechanisms come largely from animal and in-vitro work.
Dosing Protocol
28mg per day of standardized extract (commonly 14-15 mg twice daily)
Standard starting dose based on research
Therapeutic Range
28
Minimum
30
Maximum
With or without food, split morning and evening or once daily; sleep trials typically use an evening dose
Cycling Protocol
No formal cycling; most trials run 6-12 weeks. Reassess benefit after 8-12 weeks rather than continuing indefinitely by default.
Dosages are general guidelines. Individual requirements vary based on body weight, health status, and specific goals. Start with lower doses and adjust based on response.
Benefits
Primary Benefits
- Improved self-reported low mood and depressive symptoms
- Reduced self-reported anxiety
- Possible improvement in sleep quality
Secondary Benefits
Safety Information
Contraindications
Do not use if any of the following apply:
- •Pregnancy (high doses of saffron can stimulate the uterus)
- •Bipolar disorder (risk of activation or mania with mood-active agents)
- •Known allergy to Crocus or related plants (including Olea/Salsola pollen)
- •Severe depression or suicidal ideation — requires medical care, not a supplement
Drug/Supplement Interactions
May interact with the following. Consult a healthcare provider before combining:
Potential Side Effects
Some users may experience:
This is not a complete list of interactions or side effects. Individual responses vary. Always start with the lowest effective dose and monitor your response. Report any adverse effects to your healthcare provider.
Quality Markers
Look for these specific quality indicators when sourcing this compound:
- Standardized to crocin/safranal content on the label (e.g., 2-3.5% safranal or defined crocin content)
- Branded clinically studied extracts (e.g., affron, Satiereal) match trial doses
- Third-party tested for adulteration — saffron is among the most commonly adulterated spices
- Dose of 28-30 mg/day, not gram quantities of culinary spice
Trusted Certifications
Note: Supplement quality varies dramatically between brands. Cheap supplements often contain fillers, incorrect doses, or contaminants. Investing in quality products from reputable manufacturers is essential for safety and efficacy.
Evidence Profile
Evidence Score
5/10
Moderate Evidence
Some clinical trials with positive results, emerging research
Evidence Scale
8-10
Strong
5-7
Moderate
1-4
Emerging
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