Gene Therapy
Therapeutic modification of genes to treat disease, enhance function, or potentially extend lifespan.
Evidence Summary
FDA-approved therapies for specific conditions. Longevity applications (follistatin, klotho, telomerase) in early research. Liz Parrish and others self-experimenting.
Evidence Scale
Mechanism of Action
Various approaches: gene replacement, gene silencing (ASO, siRNA), gene editing (CRISPR), or gene addition. Targets root cause of genetic conditions.
Who Is This For?
Genetic diseases (approved), experimental longevity applications. Cutting-edge intervention.
Protocol & Dosing
Dose
Highly specific to therapy and target.
Frequency
Single to periodic
Duration
Usually single administration
Protocol Summary
Varies dramatically by approach. Approved therapies are disease-specific. Experimental longevity protocols available offshore.
Interactions & Precautions
Contraindications
- Varies by specific therapy
Potential Risks
- •Off-target effects
- •Immune reactions
- •Unknown long-term consequences
- •Cost
Potential Side Effects
Practitioner Notes
Clinical annotations from Dr. Goel
Approved gene therapies for specific conditions highly effective. Longevity applications promising but early. George Church Rejuvenate Bio work notable.
Dr. Sanjeev Goel
Chief Medical Officer, Peak Human
Cost & Access
Cost Range
$$$$$
Accessibility
Availability varies by location
Sample member
Longevity Operator
One number for your longevity journey.
FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.
- Metabolic
- Hormonal
- Cardiovascular
- Brain / Cognitive
- Sleep
- Musculoskeletal
- Gut
- Immunity / Inflammation