Partial Reprogramming
Transient expression of Yamanaka factors (OSKM) to reverse cellular aging without full dedifferentiation.
Evidence Summary
Groundbreaking research from Sinclair, Izpisua Belmonte labs. Mouse studies show age reversal. Human applications still experimental. Altos Labs and others well-funded.
Evidence Scale
Mechanism of Action
Brief OSKM expression resets epigenetic age markers while maintaining cell identity. May reverse tissue aging at fundamental level.
Who Is This For?
Experimental/research phase. Potentially transformative but years from clinical application.
Protocol & Dosing
Dose
Still in research phase. No established human protocols.
Frequency
Unknown
Duration
Experimental
Protocol Summary
Experimental: gene therapy or small molecule approaches to transiently express reprogramming factors.
Interactions & Precautions
Contraindications
- Not applicable - experimental
Potential Risks
- •Cancer risk
- •Teratoma formation (full)
- •Unknown long-term effects
Potential Side Effects
Practitioner Notes
Clinical annotations from Dr. Goel
Most exciting fundamental longevity research. Turn Biotechnologies, Altos Labs advancing. Years from human application but potentially transformative.
Dr. Sanjeev Goel
Chief Medical Officer, Peak Human
Cost & Access
Cost Range
N/A
Accessibility
Availability varies by location
Sample member
Longevity Operator
One number for your longevity journey.
FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.
- Metabolic
- Hormonal
- Cardiovascular
- Brain / Cognitive
- Sleep
- Musculoskeletal
- Gut
- Immunity / Inflammation