Omega-3 Fatty Acids
Essential polyunsaturated fats (EPA/DHA) supporting cardiovascular, brain, and inflammatory health.
Evidence Summary
Extensive RCT data for cardiovascular outcomes (REDUCE-IT). Well-established anti-inflammatory effects. Critical for brain health. UPDATE (August 2026): A systematic review of nutritional interventions and cellular senescence in humans (Ageing Research Reviews 2026; 27 trials, 3,811 participants) found that among dietary supplements, n-3 polyunsaturated fatty acids were the only class showing plausible modulation of selected inflammatory and SASP-related circulating markers - though the authors describe supplement evidence overall as limited and heterogeneous, and note that SASP-panel cytokines are not specific to senescent cells. This is consistent with, and adds mechanistic texture to, the established anti-inflammatory profile of omega-3s. It is not evidence that omega-3 supplementation reduces senescent-cell burden.
Evidence Scale
Mechanism of Action
Incorporated into cell membranes, modulating fluidity. Precursors to anti-inflammatory resolvins and protectins. Support cardiovascular, neurological, and immune function.
Who Is This For?
Cardiovascular risk, inflammation, cognitive support, mood disorders. Omega-3 index testing available.
Protocol & Dosing
Dose
2-4g combined EPA/DHA daily. Higher EPA for inflammation, balanced for general health.
Frequency
Daily with meals
Duration
Ongoing
Protocol Summary
Triglyceride or ethyl ester form. Take with food. EPA:DHA ratio varies by goal.
Interactions & Precautions
Contraindications
- Fish allergy (fish-derived)
- Anticoagulation (high doses)
Potential Risks
- •Oxidation if poor quality
- •Bleeding risk at high doses
Potential Side Effects
Practitioner Notes
Clinical annotations from Dr. Goel
Triglyceride form superior absorption. Check for third-party testing. Target omega-3 index >8%. EPA dominant for cardiovascular/inflammatory goals. Updated August 2026: Omega-3s were the only supplement class in the 2026 human senescence systematic review to show plausible movement on SASP-related circulating markers. Worth noting to patients interested in senescence, with the caveat the authors themselves apply - these markers are not senescent-cell-specific, so this supports the anti-inflammatory case rather than a senolytic one. Primary indication remains cardiovascular and cognitive.
Dr. Sanjeev Goel
Chief Medical Officer, Peak Human
Cost & Access
Cost Range
$
Accessibility
Availability varies by location
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