PRP Therapy
Concentrated platelet-rich plasma injections to accelerate tissue healing through growth factor delivery.
Evidence Summary
Moderate-to-strong evidence for orthopedic applications: a 2026 meta-analysis (11 RCTs, 851 patients) found PRP significantly improved overall WOMAC function scores in knee osteoarthritis versus controls, and PRP outperformed hyaluronic acid at 3, 6, and 12 months and outperformed corticosteroids at 3-6 months across multiple RCTs (Journal of Clinical Medicine review, 2025). However, the high-quality RESTORE trial found no significant PRP-vs-saline difference at 12 months, so pain-specific outcomes remain mixed even as overall function scores favor PRP; benefits appear greater in patients under 60. Hair restoration for androgenetic alopecia is well-supported by a 2025 systematic review and meta-analysis of 43 RCTs (1,877 patients, Dermatology and Therapy), showing improved hair density and reduced shedding, though effects on hair thickness were not statistically significant. Facial rejuvenation evidence remains preliminary.
Evidence Scale
Mechanism of Action
Platelets release growth factors (PDGF, TGF-β, VEGF, EGF) that stimulate tissue repair, collagen synthesis, angiogenesis, and cellular regeneration.
Who Is This For?
Tendon injuries, osteoarthritis, hair loss, facial rejuvenation. Poor response if severe tissue damage.
Protocol & Dosing
Dose
Typically 10-20ml blood yields 3-5ml PRP. Concentration varies by system. A 2026 systematic review found PRP outcomes in knee osteoarthritis correlate with the total deliverable platelet dose, underscoring that preparation system and concentration meaningfully affect results (Hooper et al., PM&R, 2026).
Frequency
Monthly for series
Duration
3-6 treatments typical
Protocol Summary
Blood drawn, centrifuged to concentrate platelets 3-8x, injected into target tissue.
Interactions & Precautions
Contraindications
- Active infection
- Blood disorders
- Anticoagulation
- Cancer at injection site
Potential Risks
- •Infection
- •Nerve damage if improperly placed
- •Limited effect in severe degeneration
Potential Side Effects
Practitioner Notes
Clinical annotations from Dr. Goel
Quality of PRP varies significantly by preparation system. Leukocyte-rich vs leukocyte-poor depends on indication. Combine with other regenerative therapies.
Dr. Sanjeev Goel
Chief Medical Officer, Peak Human
Cost & Access
Cost Range
$$
Accessibility
Availability varies by location
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