Therapeutic Plasma Exchange
Removes and replaces blood plasma to eliminate harmful autoantibodies, toxins, and pro-aging factors while refreshing the circulatory environment.
Evidence Summary
FDA-approved for 87+ conditions. Strong RCT evidence for autoimmune disorders. Breakthrough parabiosis research demonstrates rejuvenation potential through plasma dilution.
Evidence Scale
Mechanism of Action
Mechanical filtration separates plasma from blood cells. Removes autoantibodies, inflammatory cytokines, and senescence-associated factors. Fresh frozen plasma or albumin provides replacement.
Who Is This For?
Autoimmune conditions, neurological disorders, longevity optimization. Requires IV access.
Protocol & Dosing
Dose
Typically 1-1.5 plasma volumes per session.
Frequency
Weekly to bi-weekly
Duration
Varies by condition; 5-10 sessions common
Protocol Summary
Blood drawn, separated, plasma removed and replaced with albumin or FFP. 1-3 hour sessions.
Interactions & Precautions
Contraindications
- Severe hypotension
- Citrate allergy
- Active bleeding
- Hemodynamic instability
Potential Risks
- •Infection
- •Bleeding
- •Allergic reaction to replacement fluids
Potential Side Effects
Practitioner Notes
Clinical annotations from Dr. Goel
Breakthrough longevity therapy based on parabiosis research. Simple plasma dilution with albumin may offer similar benefits at lower cost.
Dr. Sanjeev Goel
Chief Medical Officer, Peak Human
Available at Peak Human
TPE is offered as a physician-supervised, biomarker-tracked clinical service at Peak Human.
View the TPE serviceCost & Access
Cost Range
$$$$
Accessibility
Availability varies by location
Sample member
Longevity Operator
One number for your longevity journey.
FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.
- Metabolic
- Hormonal
- Cardiovascular
- Brain / Cognitive
- Sleep
- Musculoskeletal
- Gut
- Immunity / Inflammation