Filter what time has deposited
Therapeutic plasma exchange.
TPE filters age-related inflammatory compounds, autoantibodies, and toxic burden from your plasma — a frontier longevity intervention with measurable downstream effects.
Format
2–3 Hour Session
Cadence
Series of 4–6
Aging is partly a story of accumulation — of inflammatory cytokines, oxidized lipids, and autoantibodies your body never fully clears.
Therapeutic plasma exchange filters those compounds physically, replacing your plasma with clean albumin. Animal data suggests measurable rejuvenation effects; human data is emerging quickly.
The strongest human evidence to date comes from a 2025 single-blind, randomized, placebo-controlled trial from the Buck Institute (Fuentealba et al., Aging Cell), which reported average reductions in multi-omic biological age of roughly 1.3 years with biweekly TPE and 2.6 years when TPE was paired with IVIG, versus placebo. Earlier controlled work in Alzheimer's disease (the AMBAR trial, 347 randomized of 496 screened) found plasma exchange with albumin was associated with slower cognitive and functional decline in the moderate subgroup. These are early findings in specific populations and are not a guarantee of individual results; we deliver TPE only in a biomarker-tracked clinical setting.
We deliver TPE in a clinical, biomarker-tracked setting — never as a one-off wellness service. Pre and post panels verify the biological effect.
What TPE does.
01
Plasma Filtration
Centrifuge separates plasma from cellular components; plasma is replaced with clean human albumin.
02
Inflammatory Reduction
Removes circulating cytokines, oxidized lipoproteins, and inflammatory mediators.
03
Autoimmune Application
Used clinically for autoantibody removal in select autoimmune presentations.
04
Longevity Layering
Layered into a broader longevity protocol — paired with bio-age tracking.
The session.
Day −7
Pre-Panel Drawn
Inflammatory, lipid, and bio-age markers established as baseline.
00:00
IV Access + Vitals
Two IV lines placed. Vitals continuously monitored throughout.
00:15
Exchange Begins
Centrifuge separates and replaces plasma with albumin over 2–3 hours.
02:30
Recovery + Discharge
30-minute monitoring before discharge with same-day follow-up call.
Day +14
Post-Panel
Same markers re-drawn to quantify the biological response.
−2.61 yr
Biological age reduction
Biweekly TPE + IVIG — Buck Institute RCT (Aging Cell, 2025)
61%
Slower cognitive/functional decline
Moderate Alzheimer's subgroup — AMBAR trial (Alzheimer's & Dementia, 2020)
347
Patients randomized
AMBAR controlled trial — 347 randomised of 496 screened
The process.
Step 01
Assess
Comprehensive intake — health history, lived experience, prior testing, and current trajectory.
Step 02
Map
Advanced biomarker panels and functional testing to map the underlying biology, not just the symptom.
Step 03
Intervene
A precision protocol — clinical interventions, lifestyle architecture, and supplementation calibrated to your data.
Step 04
Optimize
Continuous tracking, quarterly recalibration, and evolution of the protocol as your biology shifts.
§ Evidence / Biological Age
Biological age change after a TPE series
Source: Fuentealba et al., Aging Cell (2025) · Buck Institute single-blind randomized placebo-controlled trial · multi-omics biological age
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