Long-form thinking on longevity, performance & healthy aging.
Research-grounded essays from the Peak Human team. No fluff, no fads — just what the science actually shows.
Does Sharing Your Goals Help?
What the Accountability Research Actually Shows
Four longitudinal studies of 1,035 adults found people who told someone about a goal put more effort in. Yet in Gollwitzer's experiments, being noticed cut working time by 11 minutes. A physician sorts out when sharing helps and when it backfires.
Ghrelin: The Hunger Hormone
What Raises It, What Lowers It
Ghrelin is the only hormone shown to make people eat more — infusing it raised buffet intake 28%. Two nights of short sleep raise it 28%, and a year after dieting it is still elevated. A physician reviews the evidence.
Oligospermia: Do hCG, hMG or Clomiphene Work?
The Evidence, Sorted by Cause
Gonadotropins induce sperm in about three quarters of men with hypogonadotropic hypogonadism. In idiopathic low sperm count with normal FSH, the honest answer is far weaker — and testosterone is the wrong tool entirely.
How Effective Is hCG at Raising Testosterone?
The Evidence, Dose by Dose
hCG stimulates the testis to make its own testosterone — preserving intratesticular testosterone and fertility that exogenous testosterone suppresses. A physician reviews how large the rise really is, and who it works for.
Supplements for the MDMA Comedown
What the Evidence Actually Shows
The mid-week “Tuesday blues” after MDMA are real. A physician reviews the evidence behind popular “rolling supplement” stacks — vitamin C, alpha-lipoic acid, 5-HTP, EGCG, magnesium — and the serotonin-syndrome risk that matters most.
MDMA-Assisted Therapy for PTSD
What the Phase 3 Evidence Really Shows
Two phase 3 trials found large drops in PTSD severity — yet the FDA said no in 2024. A physician reviews the MDMA evidence, the mechanism, the FDA decision, and what comes next.
Ketamine for Depression
What the Evidence Really Shows
Does ketamine work for depression? A physician reviews the evidence on IV ketamine and esketamine (Spravato) for treatment-resistant depression — speed, durability, safety.
DPA: The Third Omega-3
Does Docosapentaenoic Acid Deserve More Attention?
DPA sits between EPA and DHA, often outranks EPA in blood, and was the only marine omega-3 linked to lower total coronary heart disease in a 19-cohort pooling project. A physician reviews the evidence.
Krill Oil vs Fish Oil
Which Omega-3 Absorbs Better?
Does krill oil absorb better than fish oil? A physician compares the phospholipid vs triglyceride and ethyl-ester forms, the trial evidence, dose and value.
EPA, DHA & DPA: The Three Omega-3s
What Each One Does — and Why DPA Is Overlooked
EPA, DHA and DPA are three omega-3s with three different jobs. A physician explains what each does, where to get them, and why DPA is overlooked.
Testosterone Gel vs Injection
How to Choose the Right TRT
Gel or injection for testosterone therapy? A physician compares steadiness, blood-thickening risk, transference, convenience and cost — and how to choose the right delivery method.
Testosterone's Daily Rhythm
Why It Peaks in the Morning (and Why That Matters)
Male testosterone follows a daily clock — highest at dawn, lowest in the late afternoon. How age and sleep reshape that rhythm, and why the timing of your blood test can change the diagnosis.
Testosterone Therapy and the Heart
Does TRT Cause Heart Disease? What the 2026 Evidence Shows
TRAVERSE randomised 5,246 men and found no increase in heart attack, stroke or cardiovascular death — but atrial fibrillation, clots and blood pressure tell a more specific story.
Oral Testosterone Therapy (Jatenzo)
How Effective Is It, What Is the Dose, and What Is the Trade-Off?
Oral testosterone undecanoate is now approved in Canada. What the phase 3 trials show on effectiveness, the dosing and titration schedule, and the blood-pressure caveat.
Does Plasma Exchange Actually Reverse Biological Age?
Two 2025 randomised trials, opposite conclusions
Two randomised trials published in 2025 reached opposite conclusions about whether plasma exchange lowers biological age. The difference between them — what gets put back in — is the most useful finding in the literature.
HBOT Benefits: What the Newest 2026 Research Actually Shows
Fibromyalgia, wound healing, tissue salvage and recovery
New 2026 hyperbaric oxygen therapy studies on fibromyalgia pain, diabetic wound healing, tissue salvage and exercise recovery — plus where the HBOT evidence is still thin.
NMN vs NR
Which NAD+ Precursor Actually Works? A 2026 Evidence Review
NMN and NR both raise NAD+ — but does that translate into real benefits? An evidence review of the head-to-head trial, the conversion pathway, and what a 2025 meta-analysis says about muscle and strength.
Which Creatine Is Best?
How to Choose a Creatine Supplement in 2026
Monohydrate, HCl, gummies — are all creatine supplements the same? An evidence review of which form actually works and how to judge product quality.
Hyperbaric Oxygen Therapy in 2026: What the Newest Evidence Actually Supports
A clinician's review of the 2025–2026 HBOT trials
Effect sizes, session protocols, the null results that matter, and where the HBOT signal is strongest across brain injury, cognition, long COVID and longevity.
The Rare Gene Variant Behind Families Who Age Without the Inflammation
CGAS, cGAS-STING and the biology of inflammaging
A rare CGAS variant found in long-lived Leiden families blunts cGAS-STING signalling — the pathway behind inflammaging. What the evidence shows, and its limits.
Blue Light, Melatonin and Blue Light Blockers
What the 2026 Evidence Actually Supports
A clinician's review of 2026 evidence on blue light, melatonin suppression and blue light blockers — what the data support and how to counsel patients.
Creatine Dosage & Clinical Evidence 2026
Brain, Muscle, Bone & Kidney Safety
A practitioner's review of 2025–2026 creatine trials: dosing thresholds, brain creatine uptake, strength effect sizes, and what the new kidney-function meta-analysis actually shows.
Hyperbaric Oxygen Therapy Benefits
What the Latest Research Actually Shows
Does hyperbaric oxygen therapy work? A plain-English look at the newest HBOT research on longevity, brain injury, wound healing and recovery — with the data.
Vitamin K2 (MK-7) for Heart Health
Can It Help Protect Your Arteries?
Your arteries are supposed to stay soft and flexible. New 2026 research suggests Vitamin K2 (MK-7) may help slow arterial calcification and keep calcium in your bones, not your blood vessels.
Blue Light and Sleep
Do Blue Light Blockers Really Work?
Does blue light hurt your sleep, and do blue light blocking glasses actually work? A physician-led look at the latest 2025 research on melatonin, circadian rhythm and screens.
Plasmalogens for Brain Health
Do They Actually Work?
Plasmalogens are brain lipids that fall with age and dementia. Here's what the latest research says about benefits, safety, dosage, and whether they help cognition.
Is Creatine Safe?
Benefits, Dosage & What the Latest 2026 Research Shows
Is creatine safe? New 2026 research links daily creatine to brain, muscle, and healthy-aging benefits for men and women. See the evidence, dosage, and safety.
Does Hyperbaric Oxygen Therapy Actually Work?
What the Latest Research Shows
A quick, evidence-based look at HBOT: longevity biomarkers, wound healing, post-COVID cognition and brain injury — what recent studies actually show.
Blue Light and Sleep
Do Blue Light Blockers Actually Work?
Blue light suppresses melatonin and delays your circadian rhythm. Here's what 2025–2026 research says about screens before bed and whether blue light blockers help.
Hyperbaric Oxygen Therapy in 2026
What the Newest Trials Actually Show
A clinician's review of the newest HBOT research — TBI, diabetic foot ulcers, post-COVID cognition and longevity — with protocols and effect sizes.
Blue Light and Melatonin
What the Latest Evidence Tells Clinicians About Screens, Circadian Rhythm & Blue Light Blockers
A clinical review of the latest research on blue light, melatonin suppression, and circadian phase — plus what the evidence really shows about blue light blocking glasses.
Creatine in Clinical Practice
A 2026 Evidence Review for Practitioners
A practitioner's read of the 2026 creatine evidence — dosing, brain creatine, strength meta-analyses, menopause, and safety.
Hyperbaric Oxygen Therapy for the Brain, Wounds & Longevity
What the 2025–2026 Evidence Shows
A clinician's review of the latest HBOT research on brain injury, cognition, wound healing and long COVID — protocols, effect sizes, and where the evidence stands.
Do Blue Light Glasses Work?
What New Sleep Research Actually Shows
New 2025–2026 studies on blue light, melatonin, and sleep — plus an honest look at whether blue light blockers work for adults, kids, and eye strain.
Creatine for Women
What 2026 Research Says About Brain, Muscle & Healthy Aging
Creatine isn't just for men. 2026 research links daily creatine to women's brain, muscle, and healthy-aging benefits — see the evidence, dosage, and safety.
Does Hyperbaric Oxygen Therapy Work?
What the 2025–2026 Research Shows
New 2025–2026 research on HBOT for brain injury, longevity, fibromyalgia and recovery. See the data and what it means for you.
Blue Light and Sleep
Do Blue Light Blockers Actually Work?
New research on blue light, melatonin and circadian rhythm. See what the evidence says about blue light blockers for better sleep.
Creatine for General Health
What the 2026 Research Actually Shows
A longevity-focused look at creatine: cognition in older adults, healthy aging, and an honest read of the evidence.
5 Reasons to Start Taking Creatine Today
Backed by 2025–2026 Research
Creatine isn't just for gym-goers. New research reveals benefits across muscle, brain, mood, and healthy aging.