DOSSIER 04-CHeart & Vessels
Cardiovascular
ApoB, Lp(a), atherosclerosis, prevention
Aggregated Papers
Avg Evidence Score
Clinical Trials
Signal Strength
01. Overview
Cardiovascular research here focuses on primary prevention, lipid biology, plaque progression, and the systems view of vascular aging. The best studies help prioritize biomarkers, therapies, and sequencing for long-horizon risk reduction.
Cardiovascular disease remains the dominant practical threat to lifespan, so this category emphasizes actionable prevention instead of reactive disease management.
Clinical theme
Atherosclerosis prevention
Clinical theme
Lipid optimization
Clinical theme
Inflammation and vascular damage
Clinical theme
Risk stratification
Clinical lens
A clinical lens on cardiovascular research
Cardiovascular research is where the longest, largest trials live — read it for outcomes, not surrogates.
Use this topic to ground lipid, blood-pressure, and prevention strategy in actual outcome data.
Best used for
- →ApoB and Lp(a) intervention review
- →Statin and PCSK9 evidence
- →Blood-pressure prevention strategy
- →Lifestyle vs pharma trade-offs
Signal map
- Hard outcomes outweigh surrogate endpoints
- Statin data is robust and unfashionable to defend
- Lp(a) interventions are emerging
- Prevention beats reversal almost always
Decision questions
- What was the actual mortality signal?
- Is this surrogate or hard endpoint?
- Does it apply to my risk profile?
03. The Studies
0 indexedAll research
Database index- 10-Year Coronary Heart Disease Risk Prediction Using Coronary Artery Calcium and Traditional Risk Factors: Derivation in the MESA (Multi-Ethnic Study of Atherosclerosis) With Validation in the HNR (Heinz Nixdorf Recall) Study and the DHS (Dallas Heart Study)
- 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults
- 2024: the year in cardiovascular disease — the year of lipoprotein(a). Research advances and new findings
- A Bi-Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging-Related Metabolic Dysfunction
- A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
- A consensus roadmap from the SENESCENCE2030 network towards precision senescence medicine
- A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice
- A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
- A Randomized Trial of Intensive versus Standard Blood-Pressure Control
- A transitional senescence program drives inflammatory monocyte state expansion in aging humans
- AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease (2023)
- Aging Biology Research
- Aging rate indicators and the search for anti-aging drugs
- An epigenetic biomarker of aging for lifespan and healthspan
- An open benchmark and language models for AI in aging biology
- Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials
- Assessment of the cortisol awakening response: Expert consensus guidelines
- Association between Vitamin D Supplementation and Cancer Mortality: A Systematic Review and Meta-Analysis
- Association between whole-blood NAD+ concentration and frailty in community-dwelling older adults: the Itabashi Longitudinal Study on Aging
- Association of DNA methylation-predicted growth differentiation factor 15 with all-cause mortality among older adults (NHANES 1999-2002)
- Association of Urine Albumin to Creatinine Ratio With Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus
- Associations between diet quality, epigenetic aging and epigenome in two population-based cohorts
- Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts
- Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men: Individual Participant Data Meta-analyses
- At least 54 cell-aging papers appear to have used an E. coli beta-galactosidase antibody to detect mammalian SA-beta-gal
- Beyond point estimates: quantifying predictive uncertainty reveals hidden dimensions of biological age acceleration and improves risk interpretation
- BGE-102, an oral brain-penetrant NLRP3 inflammasome inhibitor: first participant dosed in the Phase 2 QUELL-CV trial
- Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction
- Brain Health Research
- Caloric restriction modulates genome-wide somatic mutation in mice
- Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality
- Circulating magnesium levels and incidence of coronary heart diseases, hypertension, and type 2 diabetes mellitus: a meta-analysis of prospective cohort studies
- Circulating N-Linked Glycoprotein Acetyls and Longitudinal Mortality Risk
- Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups
- Criteria for confidence in epigenetic clock results in intervention studies (title not verified; DOI 10.1111/acel.70756)
- Current opinions on the role of apolipoprotein B in the clinical management of cardiovascular risk
- Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells
- Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men
- Dehydroepiandrosterone Sulfate and Mortality in Middle-Aged and Older Men and Women — A J-shaped Relationship
- Diabetes Mellitus, Fasting Blood Glucose Concentration, and Risk of Vascular Disease: A Collaborative Meta-Analysis of 102 Prospective Studies
- Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B12 status in the elderly
- Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies
- Direct AMPK activation by compound 991 extends lifespan in yeast, worms and flies
- Disruption of CDK4/6-RARalpha-NF-kB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy
- Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis
- DNA methylation GrimAge strongly predicts lifespan and healthspan
- Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs
- Dose-Response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease Incidence: A Meta-Analysis of Prospective Studies
- DunedinPACE, a DNA Methylation Biomarker of the Pace of Aging
- Effect of B Vitamins and Lowering Homocysteine on Cognitive Impairment in Patients With Previous Stroke or Transient Ischemic Attack
- Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals
- Effects of nutritional interventions on biomarkers of cellular senescence in humans: A systematic review
- Efficacy and Safety of More Intensive Lowering of LDL Cholesterol: A Meta-Analysis of Data from 170,000 Participants in 26 Randomised Trials
- Elevated remnant cholesterol reclassifies risk of ischemic heart disease and myocardial infarction
- Emerging Research
- Epigenetic age acceleration and mortality risk prediction in US adults
- Epigenetic aging clocks in tirzepatide-treated adults: SURMOUNT-5 sub-study (ARDD 2026 conference presentation, unpublished)
- Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease
- Exercise Research
- Fasting and Post-Challenge Glucose as Quantitative Cardiovascular Risk Factors: A Meta-Analysis
- Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis
- FDA clearance of the Lumipulse G pTau217/beta-amyloid 1-42 plasma ratio — first blood test to aid Alzheimer's disease diagnosis (2025)
- Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity
- Folate and global health review series, part 3: syntheses on cardiovascular, cerebrovascular, and metabolic diseases
- Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials
- FT3/FT4 ratio is correlated with all-cause mortality, cardiovascular mortality, and cardiovascular disease risk: NHANES 2007-2012
- Gamma-Glutamyl Transferase and Risk of All-Cause and Disease-Specific Mortality: A Nationwide Cohort Study
- Gamma-Glutamyltransferase and Risk of Cardiovascular Mortality: A Dose-Response Meta-Analysis of Prospective Cohort Studies
- Global bivariate meta-analysis of FIB-4 cut-offs to rule out advanced fibrosis in MASLD
- Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes
- Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes—2025
- Growth differentiation factor-15 is a biomarker for all-cause mortality but less evident for cardiovascular outcomes: a prospective study
- Gut microbiome signatures associate with DNA methylation-based biological aging
- Hbot Research
- High Level of Plasma Estradiol as a New Predictor of Ischemic Arterial Disease in Older Postmenopausal Women: The Three-City Cohort Study
- Higher Serum Free T4 Is Associated With Increased Risk of Mortality and Cerebrovascular Events in Elderly Men
- Histological aging signatures for monitoring tissue-specific aging and disease
- Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial
- Hormones Research
- How epigenetic clocks tick: unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging
- Hs-CRP as a biomarker for atherosclerosis progression and cardiovascular risk: a systematic review
- Human whole-blood NAD+ levels do not vary with age or lifestyle interventions
- Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement
- Inhibiting cyclin D1–CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline
- Insights into longevity and virus-driven adaptation from Myotis bat genomes
- Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis
- Iron Metabolic Biomarkers and the Mortality Risk in the General Population: A Nationwide Population-Based Cohort Study
- Joint impact of pathological burden and cognitive resilience on Alzheimer's disease risk
- KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease
- Late-life semaglutide treatment slows ageing and extends lifespan in female mice
- Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice
- Lipoprotein(a) as a Pharmacological Target: Premises, Promises, and Prospects
- Lithium deficiency and the onset of Alzheimer's disease
- Longevity factor klotho enhances cognition in aged nonhuman primates
- Low folate predicts accelerated cognitive decline: 8-year follow-up of 3140 older adults in Ireland
- Low Hemoglobin A1c in Nondiabetic Adults
- Low-Density Lipoproteins Cause Atherosclerotic Cardiovascular Disease. 1. Evidence from Genetic, Epidemiologic, and Clinical Studies. A Consensus Statement from the European Atherosclerosis Society Consensus Panel
- Low-Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle-Aged and Older Adults: Study Protocol for a Triple-Blind, Randomised, Placebo-Controlled Trial
- Low-dose rapamycin and cerebral blood flow in cognitively normal middle-aged adults by APOE genotype (pilot)
- Meta-analysis of DNA methylation aging signatures in 17 human tissues
- Metabolic Research
- Minimal levels of serum estradiol prevent postmenopausal bone loss
- Modulating IL-11-dependent matrix stiffness to delay ovarian aging
- Multi-Tissue Metabolomic Signatures of Five Longevity Interventions Converge on Ergothioneine and Lipid Remodeling in Male UM-HET3 Mice
- Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition
- Normoalbuminuria — is it normal? The association of urinary albumin within the 'normoalbuminuric' range with adverse cardiovascular and mortality outcomes: a systematic review and meta-analysis
- Nutrition Research
- Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis
- Omega-3 Index: an emerging biomarker in cardiovascular prevention
- OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records
- Peptides Research
- Physical activity delays ovarian aging in part through adiponectin-related signaling pathways
- Plasma GFAP is an early marker of amyloid-beta but not tau pathology in Alzheimer's disease
- Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease
- Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort
- Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
- Plasma p-tau217 in Alzheimer's disease: Lumipulse and ALZpath SIMOA head-to-head comparison
- Plasma proteome profiling identified biomarkers for the differential diagnosis and molecular staging of neurodegenerative dementias
- Plasma proteomic signatures of cellular aging predict human disease
- Plasma proteomics framework predicts metabolic dysfunction-associated steatotic liver disease up to 16 years before onset
- Profiling the molecular and physiological effects of senolytic treatment on aged mice identifies immune, fibrotic and metabolic remodeling
- Prognostic value of Alzheimer's disease plasma biomarkers in the oldest-old: a prospective primary care-based study
- Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment
- Proteomic aging clocks go to trial
- Quantification of Biological Aging in Young Adults
- Quantitative proteomics reveals coordinated changes in the proteome during replicative senescence
- Relations of GlycA and Lipoprotein Particle Subspecies with Cardiovascular Events and Mortality: A Post Hoc Analysis of the AIM-HIGH Trial
- Relationship Between Circulating Concentrations of Thyrotropin, Free Thyroxine, and Free Triiodothyronine and 9-Year Mortality in Euthyroid Elderly Subjects
- Remnant cholesterol and its visit-to-visit variability predict cardiovascular outcomes in patients with type 2 diabetes: findings from the ACCORD cohort
- Responsiveness of epigenetic aging biomarkers to longevity interventions in humans
- Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging
- Reversal of protein chemical aging by enzymatic deglycation
- Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association
- Semaglutide and cardiovascular outcomes by frailty status in SELECT (post hoc analysis)
- Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program
- Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction
- Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial
- Senotypes define the diverse landscape of senescent cells
- Serum magnesium and risk of coronary artery disease: are there implications for dietary interventions?
- Serum Triglycerides and Atherosclerotic Cardiovascular Disease: Insights from Clinical and Genetic Studies
- Serum Uric Acid and Risk of Cardiovascular Mortality: A Systematic Review and Dose-Response Meta-Analysis of Cohort Studies of Over a Million Participants
- Sex-specific biological aging clocks across organs and omics
- Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories
- Sleep Research
- Somatic mutations impose an entropic upper bound on human lifespan
- Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals
- Systematic review and meta-analyses on associations of endogenous testosterone concentration with health outcomes in community-dwelling men
- Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women
- Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice
- The Association of Ferritin with Cardiovascular and All-Cause Mortality in Community-Dwellers: The English Longitudinal Study of Ageing
- The Association of the Triglyceride-to-HDL Cholesterol Ratio with Insulin Resistance in White European and South Asian Men and Women
- The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming
- The effect of astaxanthin supplementation on inflammatory markers, oxidative stress indices, lipid profile, uric acid level, blood pressure, endothelial function, quality of life, and disease symptoms in heart failure subjects
- The Triglyceride/HDL Ratio as a Surrogate Biomarker for Insulin Resistance
- Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging
- Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve
- TNFR1 signaling connects inflammation to impaired fatty acid oxidation to drive intestinal stem cell aging
- Topical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity
- Tpe Research
- Trained immunity links hematopoietic stem cell aging to aging-associated inflammation
- Transcriptomic reprogramming screen identifies SRSF1 as a regulator of aging
- Triglyceride-Mediated Pathways and Coronary Disease: Collaborative Analysis of 101 Studies
- Vitamin B12 and Folate Status in Cognitively Healthy Older Adults and Associations with Cognitive Performance
- Vitamin B12 status, cognitive decline and dementia: a systematic review of prospective cohort studies
- Vitamin D and disease prevention in 2024: commentary on recent Endocrine Society recommendations
- Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline
- Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice
PHS
671
/ 1000
T3
Longevity Operator
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Longevity Operator
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