DOSSIER 04-CHeart & Vessels

    Cardiovascular

    ApoB, Lp(a), atherosclerosis, prevention

    Aggregated Papers
    Avg Evidence Score
    Clinical Trials
    Signal Strength

    01. Overview

    Cardiovascular research here focuses on primary prevention, lipid biology, plaque progression, and the systems view of vascular aging. The best studies help prioritize biomarkers, therapies, and sequencing for long-horizon risk reduction.

    Cardiovascular disease remains the dominant practical threat to lifespan, so this category emphasizes actionable prevention instead of reactive disease management.

    Clinical theme

    Atherosclerosis prevention

    Clinical theme

    Lipid optimization

    Clinical theme

    Inflammation and vascular damage

    Clinical theme

    Risk stratification

    Clinical lens

    A clinical lens on cardiovascular research

    Cardiovascular research is where the longest, largest trials live — read it for outcomes, not surrogates.

    Use this topic to ground lipid, blood-pressure, and prevention strategy in actual outcome data.

    Best used for
    • ApoB and Lp(a) intervention review
    • Statin and PCSK9 evidence
    • Blood-pressure prevention strategy
    • Lifestyle vs pharma trade-offs
    Signal map
    • Hard outcomes outweigh surrogate endpoints
    • Statin data is robust and unfashionable to defend
    • Lp(a) interventions are emerging
    • Prevention beats reversal almost always
    Decision questions
    • What was the actual mortality signal?
    • Is this surrogate or hard endpoint?
    • Does it apply to my risk profile?

    03. The Studies

    0 indexed
    PHS
    671
    / 1000
    T3
    Longevity Operator

    Sample member

    Longevity Operator

    The Peak Human Score · PHS v1

    One number for your longevity journey.

    FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.

    • Metabolic
    • Hormonal
    • Cardiovascular
    • Brain / Cognitive
    • Sleep
    • Musculoskeletal
    • Gut
    • Immunity / Inflammation