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Compounds
The frontier — NAD+ precursors, senolytics, autophagy enhancers, and other niche bioactives at the leading edge of longevity research. Evidence is evolving fast; quality and bioavailability vary widely.
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Compounds
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High evidence
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Clinical lens
A clinical lens on compounds supplements
The compounds lane is everything that doesn't fit the standard buckets — from creatine to taurine to specialty molecules.
Use this lane for the high-evidence, hard-to-categorise compounds that quietly do real work.
Best used for
- →Creatine for cognition and muscle
- →Taurine for cardiovascular and sleep
- →Specialty molecules for specific goals
- →Stacking with proven compounds
Signal map
- Look for human trials, not just mechanism
- Some compounds need months to show benefit
- Pure-form quality varies by supplier
- Combination effects are often understudied
Decision questions
- Is the human evidence solid?
- Am I taking it long enough to see it work?
- Is the supplier credible?
Key benefits
- •NAD+ restoration and sirtuin activation
- •Senolytic clearance of senescent cells
- •Autophagy and metabolic flexibility
- •Glucose and lipid optimization
Key considerations
- •Long-term human data still emerging
- •Bioavailability varies wildly by source
- •Some require medical supervision (Rapamycin)
Ideal for
Proactive longevity protocols
Cellular health optimization
Metabolic optimization
Notable compounds
NMN
NR (Nicotinamide Riboside)
Resveratrol
Quercetin
Fisetin
Spermidine
Berberine
Rapamycin
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Longevity Operator
The Peak Human Score · PHS v1
One number for your longevity journey.
FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.
- Metabolic
- Hormonal
- Cardiovascular
- Brain / Cognitive
- Sleep
- Musculoskeletal
- Gut
- Immunity / Inflammation