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Supplement Category
Hormones
Endocrine inputs and hormone precursors used to restore age-related decline, support sleep architecture, and rebalance the HPA axis. These require clinical guidance and lab-driven dosing.
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Clinical lens
A clinical lens on hormones supplements
Hormone-class supplements are powerful and easy to misuse — pregnenolone, DHEA, and melatonin sit between supplement and pharma.
Use this lane only with testing — these compounds shift endocrine function and deserve clinical oversight.
Best used for
- →DHEA support in deficiency
- →Pregnenolone for stress and cognition
- →Melatonin for circadian repair
- →Bridging into supervised HRT
Signal map
- Test first, dose second
- Conversion pathways change the picture
- Dose responses are non-linear
- Long-term safety data is mixed
Decision questions
- Did I test before starting?
- Is this dose physiological or pharmacological?
- Do I have clinical oversight?
Key benefits
- •Age-related hormone restoration
- •Sleep architecture and circadian support
- •HPA axis rebalancing
- •Mood, libido, and cognitive support
Key considerations
- •Always test before dosing — hormones cascade
- •Clinician-supervised dosing recommended
- •Bioidentical preferred over synthetic analogs
Ideal for
Andropause and perimenopause support
Sleep restoration protocols
Stress recovery (under medical care)
Notable compounds
Pregnenolone
DHEA
Melatonin
Progesterone
7-Keto DHEA
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All Hormones
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PHS
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Longevity Operator
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Longevity Operator
The Peak Human Score · PHS v1
One number for your longevity journey.
FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.
- Metabolic
- Hormonal
- Cardiovascular
- Brain / Cognitive
- Sleep
- Musculoskeletal
- Gut
- Immunity / Inflammation