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The frontier — NAD+ precursors, senolytics, autophagy enhancers, and other niche bioactives at the leading edge of longevity research. Evidence is evolving fast; quality and bioavailability vary widely.
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Clinical lens
A clinical lens on compounds supplements
NAD precursors are the most-hyped, most-debated lane — promising biology, mixed clinical signal, expensive to run wrong.
Use this lane intentionally — high cost, ongoing debate, requires biomarker tracking to justify.
Best used for
- →NAD-axis support in older adults
- →Pairing with senolytic protocols
- →Energy and metabolic context
- →Long-horizon longevity bets
Signal map
- Biomarker rises are clear; outcomes are not
- IV vs oral debate is unresolved
- Sourcing quality varies wildly
- Cost vs benefit deserves honesty
Decision questions
- Am I tracking NAD or just spending money?
- Is the brand credible?
- Could I get more for less elsewhere?
Key benefits
- •NAD+ restoration and sirtuin activation
- •Senolytic clearance of senescent cells
- •Autophagy and metabolic flexibility
- •Glucose and lipid optimization
Key considerations
- •Long-term human data still emerging
- •Bioavailability varies wildly by source
- •Some require medical supervision (Rapamycin)
Ideal for
Proactive longevity protocols
Cellular health optimization
Metabolic optimization
Notable compounds
NMN
NR (Nicotinamide Riboside)
Resveratrol
Quercetin
Fisetin
Spermidine
Berberine
Rapamycin
Nattokinase
Lutein + Zeaxanthin
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Database index- Acetyl-L-Carnitine (ALCAR)
- Adaptogens Supplements
- Alpha-GPC (L-Alpha-Glycerylphosphorylcholine)
- Alpha-Lipoic Acid
- Amino Acids Supplements
- Apigenin
- Arterosil (Endothelial Glycocalyx Support)
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- Berberine
- Beta-Alanine (Carnosine Precursor)
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- Black Seed (Nigella sativa)
- Boron
- Boswellia Serrata (AKBA)
- Butyrate (Sodium Butyrate / Tributyrin)
- Caffeine
- Calcium Alpha-Ketoglutarate (Ca-AKG)
- Ceylon Cinnamon (Cinnamomum verum)
- Chromium Picolinate
- Citicoline (CDP-Choline)
- Citrus Bergamot (Polyphenolic Fraction)
- Coenzyme Q10 (Ubiquinol)
- Collagen Peptides (Hydrolyzed, Types I & III)
- Compounds Supplements
- Cordyceps (C. militaris / C. sinensis)
- Creatine Monohydrate
- Curcumin (with Piperine)
- Cycloastragenol (TA-65)
- DHEA (Dehydroepiandrosterone)
- EGCG (Green Tea Extract)
- Ergothioneine
- Exogenous Ketones (Ketone Esters / BHB Salts)
- Fisetin
- Ginkgo Biloba (EGb 761)
- Glucosamine + Chondroitin Sulfate
- Glutathione (Liposomal)
- Glycine
- HMB (Beta-Hydroxy Beta-Methylbutyrate)
- Honokiol
- Hormones Supplements
- Hyaluronic Acid (Oral)
- L-Citrulline (and Citrulline Malate)
- L-Theanine
- Lemon Balm (Melissa officinalis)
- Lion's Mane (Hericium erinaceus)
- Lithium Orotate (Low-Dose)
- Lutein + Zeaxanthin
- Magnesium Glycinate
- Magnesium L-Threonate
- Melatonin
- Methylated B-Complex
- Milk Thistle (Silymarin)
- Minerals Supplements
- Myo-Inositol
- NAC (N-Acetyl Cysteine)
- NAD+ Precursors (NMN)
- Nattokinase
- Nicotinamide Riboside (NR)
- Nootropics Supplements
- Omega-3 Fish Oil
- Panax Ginseng (Korean/Asian Ginseng)
- Pasteurized Akkermansia Muciniphila
- Pentadecanoic Acid (C15:0)
- Peptides Supplements
- Phosphatidylserine (PS)
- Pine Bark Extract (Pycnogenol)
- PQQ (Pyrroloquinoline Quinone)
- Probiotics (Multi-Strain)
- Psyllium Husk
- Pterostilbene
- Purified Shilajit
- Quercetin
- Resveratrol
- Rhodiola Rosea
- Saffron Extract (Crocus sativus)
- Selenium
- Spermidine
- Sulforaphane (Broccoli Sprout Extract)
- Tart Cherry (Montmorency) Extract
- Taurine
- Tongkat Ali
- TUDCA (Tauroursodeoxycholic Acid)
- Urolithin A
- Vitamin C (Liposomal)
- Vitamin D3 + K2
- Vitamins Supplements
- Zinc + Copper
PHS
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Longevity Operator
The Peak Human Score · PHS v1
One number for your longevity journey.
FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.
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