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Compounds
The frontier — NAD+ precursors, senolytics, autophagy enhancers, and other niche bioactives at the leading edge of longevity research. Evidence is evolving fast; quality and bioavailability vary widely.
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Compounds
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Clinical lens
A clinical lens on compounds supplements
NAD precursors are the most-hyped, most-debated lane — promising biology, mixed clinical signal, expensive to run wrong.
Use this lane intentionally — high cost, ongoing debate, requires biomarker tracking to justify.
Best used for
- →NAD-axis support in older adults
- →Pairing with senolytic protocols
- →Energy and metabolic context
- →Long-horizon longevity bets
Signal map
- Biomarker rises are clear; outcomes are not
- IV vs oral debate is unresolved
- Sourcing quality varies wildly
- Cost vs benefit deserves honesty
Decision questions
- Am I tracking NAD or just spending money?
- Is the brand credible?
- Could I get more for less elsewhere?
Key benefits
- •NAD+ restoration and sirtuin activation
- •Senolytic clearance of senescent cells
- •Autophagy and metabolic flexibility
- •Glucose and lipid optimization
Key considerations
- •Long-term human data still emerging
- •Bioavailability varies wildly by source
- •Some require medical supervision (Rapamycin)
Ideal for
Proactive longevity protocols
Cellular health optimization
Metabolic optimization
Notable compounds
NMN
NR (Nicotinamide Riboside)
Resveratrol
Quercetin
Fisetin
Spermidine
Berberine
Rapamycin
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The Peak Human Score · PHS v1
One number for your longevity journey.
FICO for credit. PHS for longevity. Eight biological domains collapsed into one provable score — intuitive at a glance, rigorous underneath.
- Metabolic
- Hormonal
- Cardiovascular
- Brain / Cognitive
- Sleep
- Musculoskeletal
- Gut
- Immunity / Inflammation